Cough with blood, the first sign of this serious autoimmune disease

Cough with blood, the first sign of this serious autoimmune disease

Goodpasture syndrome is a rare autoimmune disease that will affect your lungs and kidneys. The main manifestations of the disease are cough accompanied by blood and glomerulonephritis.

Disease prognosis is closely related to rapid diagnosis and early treatment initiation.

People with Goodpasture syndrome develop substances that attack a protein (Goodpasture antigen) from the collagen structure of alveolar sachets in the lungs and kidney filtration units (glomeruli). These substances are called glomerular basal anti-membrane antibodies (Ac anti-MBG). Doctors say the disease occurs when the immune system attacks and mistakes the healthy tissue.

Goodpasture syndrome is typically characterized by double pathology: renal and pulmonary. Doctors also say that this autoimmune condition can be triggered by exposure to smoke and respiratory infections as well.

The main symptoms and signs in the kidney are:

  • hematuria,
  • dark urine,
  • edema,
  • back pain, under cost,
  • swelling of hands and feet,
  • hypertension,

At the pulmonary level, the signs and symptoms are:

  • cyanosis,
  • cough accompanied by blood,
  • dyspnoea,

Also, the patient may have an increased sensation of nausea, vomiting, anemia, facial pallor, fatigue.

Careful! Physicians draw attention to the fact that Goodpasture's syndrome is a serious condition because it is manifested by the production of bleeding in the lungs, and another serious consequence of the disease is the occurrence of renal failure. That's why many patients get dialysis or kidney transplantation.

Diagnosis is hard to determine and requires some analysis. Specifically, the suspect will perform blood tests, serological tests, urine summary, pulmonary radiography. Sometimes, kidney biopsy will also be done because the presence of Goodpasture's syndrome can be established.

What is the treatment:

The main purpose of treatment is to remove antibodies from the circulatory system.

The procedure that allows the removal of harmful antibodies in the blood is called plasmapheresis.

Also, by treatment, physicians aim to gain good blood pressure control and prevent serious kidney or lung lesions. The treatment usually includes immunosuppressive oral drugs, medicines to reduce the production of immune systemic antibodies. Patients with pulmonary haemorrhage will also receive injectable corticosteroids.

At the same time, the patient will receive treatment for anemia, but also anti-inflammatory drugs. He will also dialysis if there is serious kidney damage, or, more severely, kidney transplant if the kidneys are no longer functional.

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