How can people renew their cartilage or joints affected by osteoarthritis

Why do joint pain occur when the weather changes

An amazing capacity of the human body has been discovered! One study surprised the entire medical world with its results.

Like salamanders or zebrafish, people can regenerate their tissues, a capability that can be used to renew cartilage or joints affected by osteoarthritis, according to an article published Wednesday by Science Advances magazine, quoted by EFE.

A team of researchers at Duke University in North Carolina (US) has identified a cartilage repair mechanism that is stronger in the heel than in other parts of the body. This finding could develop treatments against osteoarthritis, the usual or the one that intervenes in old age and leads to cartilage loss or bone deformity.

Researchers have developed a method to determine the age of proteins using internal "molecular clocks" of amino acids that transform in one form or another with predictable regularity. While newly created proteins have little or no conversion to amino acids, the older ones are more prolific, writes Agerpres.

Understanding this process allowed researchers to use mass spectrometry – an analysis technique that determines the distribution of molecules in a substance – to identify when the key proteins of human cartilage, including collagen, are young, adult, or old.

Thus they found that the age of the cartilage depends largely on what part of the body it is. The cartilage from the heel is young, from the knee is adult, and the one from the hips is the oldest.

This explains why some people's injuries to their hips or knees require more time to heal and often lead to osteoarthritis than those that occur in heels that heal faster.

The relationship between the age of human cartilage and where it is in the body is similar to how the limbs repair to certain amphibians, which regenerate their farther parts, such as the limbs or tail.

The researchers found that this process is regulated by microRNA (ribonucleic acid) molecules that are more active in these animals known for their ability to repair their limbs, fins in the case of zebrafish, or tails for salamanders, tritons or some lizards. .

"It was extremely exciting to discover that the regulators of limb regeneration in salamanders also appear to be the ones controlling tissue repair in human joints," said Ming-Feng Hsueh, lead author of the study.

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